Atherosclerosis is a major cause of death in developed countries. To understand disease pathobiology and the underlying biological processes, a European study developed an integrated computational model framework.
Atherosclerosis is a condition associated with the thickening of the artery wall due to plaque build-up and accumulation of white blood cells. This condition affects blood flow and modifies the interaction of blood components with the deformed arteries. Although a number of parameters such as LDL concentration influence atheroma formation, we lack an integrated model that unifies blood flow dynamics and arterial wall mechanics.
Further details: A model for atherosclerosis