Molecules behind insoluble protein deposits

Many degenerative conditions are caused by the accumulation of insoluble amyloid protein aggregates. Finding ways to prevent or reverse this phenomenon is at the forefront of biomedical research and development.

Familial amyloidosis is a rare inherited condition characterised by the build-up of abnormal deposits of the protein transthyretin (TTR) in various organs. Nearly 100 mutations in the TTR gene are known to cause amyloidosis. Affected individuals show early and severe impairment of the autonomous nervous system and also visual deterioration.

Further details: Molecules behind insoluble protein deposits