Modulating cellular function by interfering with the human proteome is a rapidly growing field. European researchers succeeded in controlling the level of cellular proteins through molecules that facilitate protein degradation.
Under physiological conditions, cells constantly synthesise and destroy proteins, a phenomenon known as homeostasis. The most common degradation pathway for proteins is the ubiquitin-proteasome system, which recognises ubiquitin tags on proteins and guides them to the proteasome for hydrolysis.
Further information: Novel inhibitors target proteins for degradation