Molecular players of protein aggregation

Neurodegenerative disorders are increasing in prevalence. Understanding the molecular mechanism of disease pathophysiology is fundamental to the design of novel therapies.

Several neurodegenerative disorders, such as Alzheimer's, Parkinson's and Huntington's diseases, are characterised by the formation of pathogenic amyloid fibrils in the brain. Several proteins in both humans and bacteria naturally organise into fibrils and demonstrate a variety of structural and regulatory functions. However, the cellular process of aggregation, its regulation and the toxicity generated are not completely understood.

Further details: Molecular players of protein aggregation