Optimisation and control in chemical and biopharmaceutical processes

The project OPTICO aimed at overcoming the present limitations on implementing Process Intensification (PI) by establishing a new methodological design approach for sustainable, intensified chemical/biopharmaceutical plant design and operation through a flexible, integrated multi-scale modelling framework coupled with advanced process analytics tools and modern optimisation/control techniques. The integrated framework was applied to four industrial processes, namely, a monoclonal antibodies production/purification system, a pharmaceutical crystallization process, polymerization (i.e., suspension and inverse suspension) processes and an organic oxidation with hydrogen peroxide process.

Within the OPTICO (Model-based optimization & control for process-intensification in chemical and biopharmaceutical systems) project, a new adaptive, integrated methodological framework was developed for intensified chemical/ biopharmaceutical plant design and operation that will offer concrete opportunities to chemical/biochemical enterprises in four areas: costs, safety, time to market, and company image.

Further details: Optimisation and control in chemical and biopharmaceutical processes