European researchers are investigating the mechanism by which proteins fold to assume their functional conformation. This information will help comprehend what goes wrong in conditions associated with protein misfolding.
Proteins are major players in cellular composition and function, and their role is governed by their three-dimensional conformation. To ensure correct protein folding, cells utilise specific molecular chaperones. Failure to fold leads to inactive proteins that eventually get degraded. Sometimes, misfolded proteins form and this can lead to diseases such as Alzheimer’s disease.
Further details: Dissecting protein folding