Delineating the three-dimensional structure of proteins or protein complexes is central to comprehending their function. More importantly, structural characterisation provides the framework for drug design.
Cell growth and proliferation are fundamental processes tightly regulated through complex networks of signalling pathways that respond to environmental cues. The serine/threonine kinase mechanistic target of rapamycin (mTOR) pathway is a crucial nutrient and energy-sensitive pathway that responds to the intracellular energy state.
Further details: Structural delineation of the mTOR pathway