Cell transplantation is a promising new approach for organ regeneration in disease or after injury. To support the differentiation of hepatocytes from stem cells, European researchers developed ex vivo organoids which precisely mimic liver architecture.
Inherited cholestatic disorders (ICDs) are characterised by defects in bile synthesis and secretion, leading to progressive liver disease. Many ICD patients do not respond to medical treatment and need liver transplantation. With 10% of patients dying while waiting on the transplant list due to shortage of liver donors, there is an imminent need for alternative therapies.
Further details: Organoids to treat liver diseases