Control of the iRhom2 protein may hold the key to preventing Alzheimer’s disease

A quarter of people over the age of 65 are directly affected by AD, characterised by memory loss and cognitive decline, with dramatic socio-economic impacts. The iRhom2 in AD project set out to bring us closer to not only a cure, but also prevention.

It is known that the onset of Alzheimer’s disease (AD) is associated with the accumulation of Amyloid beta (Aβ) peptides in small molecular clusters known as oligomers. These trigger the formation of so-called ‘neurofibrillary tangles’ within neurons hamper their workings, ultimately causing cell death and so significant cognitive decline. Very large Aβ oligomers which form plaques outside neurons, alongside neuroinflammation have also been found to play a key part in the progression of the disease.

Further details: Control of the iRhom2 protein may hold the key to preventing Alzheimer’s disease