Cancer constitutes a leading cause of mortality worldwide with millions of deaths every year. Knowledge at the molecular level of the underlying mechanisms of cancer initiation and progression is necessary for effective disease treatment.
In normal cells, nearly all cellular processes are carefully regulated through modulation of protein structure, localisation and function. This takes place through protein ubiquitination, a post-translational modification of proteins that determines their activity, cellular location or guides them to proteolysis.
Further details: Pathways driving tumour biology