Chronic liver diseases (CLD) are the leading causes of morbidity and mortality worldwide with enormous socio-economic costs. Research into the molecular mechanisms that cause these diseases will help in the design of effective treatments.
CLDs and their end-stages – cirrhosis and hepatocellular carcinoma (HCC) –are caused by chronic hepatitis C (HCV) and B (HBV) virus infections, alcohol abuse and non-alcoholic steatohepatitis (NASH) as a result of metabolic syndrome. Liver transplantation is currently the only available therapy for terminal liver failure, which is however associated with many complications.
Further details: Novel treatments against chronic liver diseases