Synaptic pathology is an early sign of Alzheimer’s disease (AD). European scientists investigated how this could be a result of impaired intracellular trafficking and could contribute to disease onset.
AD is characterised by an aberrant accumulation of beta-amyloid (Aβ) at neuronal synapses, leading to dysfunction and rendering difficult the formation of new synapses. This leads to memory loss in patients suffering from the disease.
Further details: Impaired intracellular trafficking triggers Alzheimer’s disease