A novel player in T cell responses

Many immune-related diseases are caused by impaired or aberrant T cell function. Understanding T cell signalling is a major challenge for determining the aetiology of human pathologies and developing specific therapies.

A critical component of the immunological response to foreign protein is the activation of T lymphocytes. This takes place through the recognition of peptide-loaded major histocompatibility (MHC) molecules by the T-cell receptor (TCR) that initiates a series of downstream signalling events. The outcome of this complex signalling network is the activation and differentiation of T cells into subsets with specific and adapted immune function.

Further details: A novel player in T cell responses