Neoplastic transformation is usually associated with mutations, epigenetic changes and altered gene expression. Understanding the impact of these changes in the physiological protein interaction network is central for the design of novel therapies against cancer.
The epidermal growth factor receptor (EGFR/ErbB) network constitutes one of the most important signalling pathways as it regulates key developmental processes including cell proliferation and differentiation. Various oncogenic perturbations hijack the EGFR pathway, altering the proteins interaction landscape, and hence, the final cellular response. Given its implication in cancer development, there is a great interest to understand the molecular details underlying EGFR signalling.
Further information: Protein interactions and signalling in cancer