Autoimmunity is a chronic inflammatory condition mediated by T and B lymphocytes. Current treatments fail to cure the disease, necessitating alternative targeted solutions.
Development of autoimmunity involves impairment of the mechanisms of lymphocyte selection. This leads to production of autoantibodies that can trigger immune responses to various tissues and organs. Several types of immune cells and biological processes have been implicated in autoimmunity, including the aberrant stimulation of B cells by CD4+ T cells.
Further information: Single nucleotide polymorphisms in autoimmunity-associated genes