Haemorrhagic shock (HS) and systemic inflammation followed by multiple organ failure are the main causes of mortality worldwide. European scientists studied the molecular triggers of shock using an innovative framework of the autodigestion hypothesis.
Current therapeutic management of HS includes restoring tissue perfusion and maintaining blood pressure stability through intravenous fluid support. However, this approach is often ineffective in preventing organ failure, resulting in high mortality rates. The goal of the EU-funded CELSYS SHOCK (Autodigestion in haemorrhagic shock and acute heart failure: a cell-to-system approach to pathophysiology and therapy) study was to identify the cause of haemodynamic instability, specifically shock-induced heart failure, and to propose a novel therapeutic strategy.
Further information: Molecular triggers of haemorrhagic shock