Every year, there are more than a million new cases of breast cancer. Given the high rate of metastasis-associated mortality, there is an imminent need to investigate the cellular and biochemical mechanisms of metastasis.
During tumorigenesis and metastatic progression, cancer cells undergo metabolic rewiring to adapt to stringent microenvironments. Such metabolic changes can be controlled by several oncogenic pathways, such as the PI3K/AKT pathway, which is frequently activated in breast cancer. This association of metastasis and metabolic alteration presents a unique window for therapeutic targeting.
Further details: Metabolic rewiring during cancer metastasis