Neuroinflammation is a key process associated with neurodegenerative diseases. Understanding the underlying mechanism is central for the identification of novel therapeutic targets.
NADPH oxidases (NOX) are transmembrane enzymes that utilise NADPH and oxygen as substrates to catalyse the formation of superoxide and hydrogen peroxide. Under physiological conditions, NOX are essential mediators of host defence, and mutations cause an immunodeficiency known as chronic granulomatous disease.
Further details: In search of therapeutic targets for neurodegeneration