Imaging cell activation pathways

Cells translate environmental cues into intracellular responses by engaging cell membrane receptors. Delineating cell transduction pathways at the single molecule level requires cutting edge technology.

During cell activation, the transduction of information inside the cells depends on transient and heterogeneous signalling complexes that involve surface receptors, intracellular and adapter proteins. Such microclusters play a crucial role in T cell activation and affect the ability of the immune system to adequately respond to foreign pathogens.

Further details: Imaging cell activation pathways