Insight into the pathophysiology of TRAPS

European researchers shed light on a rare genetic disorder of the immune system called TNF receptor associated periodic syndrome (TRAPS). The new scores and outcome measures for diagnosis and treatment should help improve the quality of life of patients.

Patients suffer from recurrent episodes of fever and pain with renal amyloidosis being the most serious and potentially fatal complication in nearly 20 % of the cases. The disease usually commences in infancy, and treatment mainly consists of corticosteroids, and more recently anti-TNF therapeutics but with inconsistent efficacy.

Further information: Insight into the pathophysiology of TRAPS