RNA: The landmark in health and disease

RNA molecules are well-established key targets in various diseases and have served as tools for the development of new drugs. Research into the role of non-protein coding RNA (ncRNA) in disease unravels novel therapeutic targets.

Nearly 98 % of our genome leads to ncRNAs. Recent reports provide compelling evidence on the regulatory role of ncRNAs, challenging existing perception on the role of proteins as master regulators of cellular processes. ncRNAs have diverse functions in eukaryotic cell and developmental biology with an emerging contribution to the development of human disease. This has triggered great interest in the pharmaceutical and clinical fields towards the development of RNA-based drugs for the treatment of many diseases.

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